Metabolic Disruptions in Serum Calcium and Phosphate Levels Among Pre-Diabetic and Type 2 Diabetic Patients: Serum Calcium and Phosphate Levels in Diabetes Mellitus

Abroo Fatima Qazi; Najeeb ur Rahman; Saira Mushtaq; Roomisa Anis; Mahvesh Mahmud; Mudasar Pervaiz

doi:10.54393/pjhs.v5i07.1680

Authors

Abroo Fatima Qazi Department of Physiology, Isra University, Hyderabad, Pakistan https://orcid.org/0000-0003-3386-5089
Najeeb ur Rahman Institute of Kidney Diseases Hayatabad, Peshawar, Pakistan
Saira Mushtaq Aziz Fatima Medical and Dental Collage, Faisalabad, Pakistan
Roomisa Anis Department of Biochemistry, National University of Sciences and Technology School of Health Science, Islamabad, Pakistan
Mahvesh Mahmud Department of Nephrology, Watim Medical College, Rawalpindi, Pakistan
Mudasar Pervaiz Department of Community Medicine, Al-Nafees Medical College, Islamabad, Pakistan

DOI:

https://doi.org/10.54393/pjhs.v5i07.1680

Keywords:

Diabetes Mellitus, Prediabetes, Fasting Blood Glucose, Serum Calcium

Abstract

Diabetes mellitus is a metabolic disorder classified by persistently raised blood sugar levels. Objective: To identify diabetes mellitus disturbances in serum calcium and phosphate levels. However, the exact mechanisms underlying this association were not fully understood. Methods: It was a cross sectional study. It was conducted at Isra University Hospital, Hyderabad from March 2023 to August 2023. 170 patients were selected with 85 patients in each group. Group A included patients with diabetes and Group B included patients with prediabetes with fasting blood glucose levels of 101-125 mg/dl or HbA1c levels of 5.7-6.4%. Fasting blood glucose levels, HbA1c levels, total serum calcium levels and serum phosphate levels were compared. Data were assessed by using SPSS version 24.0. P-values of ≤0.05 will be statistically significant. Results: This study has shown that in both in Group A and Group B, the mean age was 47.2 ± 8.4 years and 48.5 ± 7.6 respectively (p value=0.62). Group A exhibited a mean fasting plasma glucose level of 109.34 mg/dl ± 17.92 and Group B 140.59 mg/dl ± 31.03. Group A displayed a mean serum phosphate level of 3.79 mg/dl ± 1.31, while Group B exhibited mean level of 4.43 mg/dl ± 1.04 (p=0.03). Group A demonstrated a mean serum calcium level of 8.41 mg/dl ± 1.03, whereas Group B had serum calcium level of 8.01 mg/dl ± 0.98 (p=0.02). Conclusions: The findings underscore the intricate relationship between metabolic disorders and mineral homeostasis, highlighting the potential implications for clinical management and risk stratification in diabetic patients.

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