@article{Nasir_Arslan Zahid_Saleh_Ahmed_Wirk_Khan_2023, place={Pakistan}, title={Use of Ketamine, Propofol and Their Combination (KETOFOL) For Procedural Sedation in Emergency Department: A Review: Ketamine, Propofol and their combination (Ketofol) for Procedural Sedation}, volume={4}, url={https://thejas.com.pk/index.php/pjhs/article/view/539}, DOI={10.54393/pjhs.v4i02.539}, abstractNote={<p>For Procedural Sedation, sedative and Analgesic agents are frequently used in Emergency Department but titration of anesthetic doses should be performed with care, and patients should be continuously monitored. The use of Ketamine, Propofol and their combination (Ketofol) is in common practice, but there is currently no intravenous anesthetic agent that is ideal. Therefore, this review was conducted to analyze the efficacy as well as the potential side effects of these anesthetic agents during procedural sedation. <strong>Method:</strong> For this purpose, Medline, EMBASE, CCRCT and CINAHL were searched and systematically analyzed and the meta-analysis included all English-language randomized control trials (RCTs) comparing K-P vs propofol for procedural sedation in ED. The study included the data of ED patients who received procedural sedation for non-elective unpleasant procedures. <strong>Results:</strong> As a result of the removal of duplicate citations and studies that did not fulfill eligibility requirements, a total of 06 RCTs involving 932 patients (412 in the propofol group and 520 in the K-P group). Very high levels of inter-rater reliability (j = 0.88; 95% CI = 0.68 to 1.0) were found in the final selection of included trials, with 95.2% agreement. <strong>Conclusion:</strong> Data revealed that the combination of Ketamine with propofol was the most effective anesthetic combination in the larger randomized, prospective studies carried out in the ED that had sufficient power to use the maintenance of vital signs and the success of the procedure as endpoints are still required</p>}, number={02}, journal={Pakistan Journal of Health Sciences}, author={Nasir, Huma and Arslan Zahid, Muhammad and Saleh, Muhammad and Ahmed, Shafique and Wirk, Reeba and Khan, Bahram}, year={2023}, month={Feb.}, pages={05–11} }