Local Recurrence Rate after Clear Margins in Wide Local Excision in Soft Tissue Sarcoma 2 Years after Index Surgery: Local Recurrence Following Wide Local Excision in Soft Tissue Sarcoma

Awais Iqbal; Zohaib Nadeem; Linta Masroor; Sohail Hafeez; Hasnain Ali; Syed Muneeb Asim

doi:10.54393/pjhs.v6i11.3263

Authors

Awais Iqbal Department of Orthopedic Surgery, Shifa International Hospital, Islamabad, Pakistan
Zohaib Nadeem Department of Orthopedic Surgery, Shifa International Hospital, Islamabad, Pakistan
Linta Masroor Shifa College of Medicine, Shifa Tameer-e-Millat University, Islamabad, Pakistan
Sohail Hafeez Department of Orthopedic Surgery, Shifa International Hospital, Islamabad, Pakistan
Hasnain Ali Department of Orthopedic Surgery, Shifa International Hospital, Islamabad, Pakistan
Syed Muneeb Asim Department of Orthopedic Surgery, Shifa International Hospital, Islamabad, Pakistan

DOI:

https://doi.org/10.54393/pjhs.v6i11.3263

Keywords:

Recurrence, Clear Margins, Soft Tissue Sarcoma

Abstract

Soft tissue sarcomas include a diverse collection of uncommon, malignant neoplasms originating in mesenchymal tissues. Recent cancer studies indicate that they comprise around 1% of all malignancies globally. Objectives: To evaluate the incidence of local recurrence among patients who achieved clear surgical margins following wide local excision for soft tissue sarcoma. Methods: This cross-sectional retrospective study was conducted at the Orthopedic Department of Shifa International Hospital, Islamabad. Sixty patients participated in this investigation. In this investigation, patients who underwent wide local excision and attained clear surgical margins were enrolled after being diagnosed with histologically confirmed soft tissue sarcoma. Results: The study included 60 sarcoma patients (63.3% males, mean age 46.15 ± 22.74 years). Two-year recurrence occurred in 8 (13.3%) cases, mostly synovial sarcoma. Recurrence showed no significant association with histologic subtype, therapy type, surgical margin, or tumor grade (p>0.05). Conclusions: This study corroborates existing literature on the recurrence patterns of STS, emphasizing the significance of histological subtypes, comorbidities, and surgical margins in influencing patient outcomes. Continued research into the molecular underpinnings of STS and the development of targeted therapies are crucial for improving prognosis and reducing recurrence rates.

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