Effect of Dexamethasone Versus Triamcinolone Acetonide On Postoperative Complications After Impacted Third Molar Surgery

Effect of Dexamethasone vs. Triamcinolone Acetonide on Third Molar Surgery

Authors

  • Imam Bux Khalti Department of Oral and Maxillofacial Surgery, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan
  • Tarique Hussain Shaikh Department of Oral and Maxillofacial Surgery, Isra University, Hyderabad, Pakistan
  • Aftab Ahmed Kumbhar Department of Oral and Maxillofacial Surgery, Bhitai Dental and Medical College, Mirpurkhas, Pakistan
  • Saadia Siddique Department of Oral and Maxillofacial Surgery, Jinnah Medical and Dental College, Karachi, Pakistan
  • Munir Hussain Zardari Department of Oral and Maxillofacial Surgery, Dow University of Health Sciences, Karachi, Pakistan
  • Seerat-ul-Urooj Bhutto Department of Oral Pathology, Muhammad Dental College Ibne-E- Sina University, Mirpurkhas, Pakistan
  • Kashif Ali Channar Department of Oral and Maxillofacial Surgery, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan

DOI:

https://doi.org/10.54393/pjhs.v5i08.1982

Keywords:

Impacted Tooth, Dexamethasone, Triamcinolone Acetonide, Wisdom Tooth Surgery

Abstract

In the area of maxillofacial surgery, taking out of impacted teeth, particularly third molars represents a common practice. Corticosteroids play a substantial role in reducing edema and have been found to have anti-inflammatory belongings. Objective: To compare the outcome of Dexamethasone vs. Triamcinolone Acetonide after impacted third molar surgery. Methods: A quasi-experimental study was organized the Department of Oral and Maxillofacial Surgery, Liaquat University of Medical and Health Sciences, Jamshoro/Hyderabad. A total of 288 patients with Mesioangular impaction of mandibular 3rd molar tooth were placed into two groups at random. Group-A (Dexamethasone Injection) 4mg was injected instantly into the submucosal at about 1cm above the surgical area and in Group-B (Triamcinolone Acetonide Injection) 4mg was also injected immediately at the same place. Measurements were made on the mouth opening, severity of pain, and swelling. Results: The mean pain score was significantly lower in group B than in group A on the 7th postoperative day (p = 0.0005). Mean facial swelling size was not statistically significant between groups at 2nd day but it was significantly low in group B as compared to group A at 5th and 7th postsurgical days. Mean mouth opening was also significantly higher in group B than in group A at the 5th and 7th postoperative days (p = 0.0005). Conclusions: Submucosal applying corticosteroid medication may be a very painless, effective, cheap, less hazardous, simpler technique for both the patient and the doctor, and its systemic effect is limited.

References

Praneetha S, Shenoy V, Christopher P, Gopi G, Manonmani B. Pre-emptive Single Dose of Intramasseteric Administration of Dexamethasone Versus Methylprednisolone in Surgical Extraction of Impacted Mandibular Third Molars: Prospective Split-Mouth, Randomised Triple Blinded Clinical Study. Journal of Maxillofacial and Oral Surgery. 2024 Apr; 23(2): 424-9. doi: 10.1007/s12663-023-02074-4. DOI: https://doi.org/10.1007/s12663-023-02074-4

Pimenta RP, Takahashi CM, Barberato-Filho S, McClung DC, Moraes FD, de Souza IM et al. Preemptive use of anti-inflammatories and analgesics in oral surgery: a review of systematic reviews. Frontiers in Pharmacology. 2024 Jan; 14: 1303382. doi: 10.3389/fphar.2023.1303382. DOI: https://doi.org/10.3389/fphar.2023.1303382

Singh A, Pentapati KC, Kodali MV, Smriti K, Patil V, Chowdhary GL et al. Efficacy of Preemptive Dexamethasone versus Methylprednisolone in the Management of Postoperative Discomfort and Pain after Mandibular Third Molar Surgery: A Systematic Review and Meta‐Analysis. The Scientific World Journal. 2023 Apr; 2023(1): 7412026. doi: 10.1155/2023/7412026. DOI: https://doi.org/10.1155/2023/7412026

Mahmoud NR. Efficacy of sub-mucosal, intra-masseteric and intra-muscular routes of dexamethasone administration on post-operative complications following impacted mandibular third molar surgeries, comparative clinical trial. Egyptian Dental Journal. 2019 Jan; 65(1-January (Oral Surgery)): 113-33. doi: 10.21608/edj.2015.71254. DOI: https://doi.org/10.21608/edj.2015.71254

Cherian NM, George AJ, Panackel AS, Sman RR, Issac AV. Postoperative evaluation, after surgical removal of mandibular third molar, with and without local administration of injection dexamethasone 8 mg: A comparative study. International Journal of Preventive and Clinical Dental Research. 2019 Apr; 6(2): 35-8. doi: 10.4103/INPC.INPC_30_19. DOI: https://doi.org/10.4103/INPC.INPC_30_19

Shad S, Mahmud A, Shahnawaz A, SM HS, Farooq A, Khan SM et al. Use of Preoperative Submucosal Dexamethasone in Third Molar Surgery: A Step towards Improvement in Quality of Life. Journal of Ayub Medical College, Abbottabad. 2020 Oct; 32(4): S607-11.

Priyanga R, Balamurugan R, Rajan PS. Comparison of dexamethasone administration through sublingual and intramuscular routes for evaluation of pain, swelling, and trismus after impacted mandibular third molar surgery—a prospective randomized controlled study. Oral and Maxillofacial Surgery. 2022 Mar; 26(1): 155-9. doi: 10.1007/s10006-021-00978-4. DOI: https://doi.org/10.1007/s10006-021-00978-4

Vivek GK, Vaibhav N, Shetty A, Mohammad I, Ahmed N, Umeshappa H. Efficacy of various routes of dexamethasone administration in reducing postoperative sequelae following impacted third molar surgery. Annals of Maxillofacial Surgery. 2020 Jan; 10(1): 61-5. doi: 10.4103/ams.ams_66_19. DOI: https://doi.org/10.4103/ams.ams_66_19

Selvido DI, Bhattarai BP, Niyomtham N, Riddhabhaya A, Vongsawan K, Pairuchvej V et al. Review of dexamethasone administration for management of complications in postoperative third molar surgery. Journal of the Korean Association of Oral and Maxillofacial Surgeons. 2021 Oct; 47(5): 341. doi: 10.5125/jkaoms.2021.47.5.341. DOI: https://doi.org/10.5125/jkaoms.2021.47.5.341

Imon AA, Akhter M, Costa PD, Sabrina F, Haque N. Comparative study for effectiveness of oral dexamethasone for assessment of pain, swelling and trismus following impacted 3rd molar surgery. SVOA Dentistry. 2021 Jan; 2(1): 20-4.

Agrawal A, Chandel S, Singh N, Tiwari AK, Singh AK, Singh G. The efficacy of intralesional dexamethasone versus intravenous dexamethasone in surgery for impacted third molars: a randomized controlled trial. National journal of maxillofacial surgery. 2020 Jan; 11(1): 94-7. doi: 10.4103/njms.NJMS_46_17. DOI: https://doi.org/10.4103/njms.NJMS_46_17

Jamwal VS and Raje Y. Effect of dexamethasone on postoperative swelling in patients undergoing impacted molar surgery. International Journal of Surgery. 2022 Mar; 6(2): 30-2. doi: 10.33545/surgery.2022.v6.i2a.880. DOI: https://doi.org/10.33545/surgery.2022.v6.i2a.880

"Intralesional Steroid Therapy (Patient Information Leaflets)". British Association of Dermatologists. 2008. [Updated; November 2022].

Srinivasulu Y, Wahab A, Murugan PS. Comparison of Submucosal Injection of Dexamethasone and Triamcinolone Acetonide for Control of Postoperative Pain after Impacted Mandibular Third Molar Surgery- A Prospective Randomized Controlled Trial. Journal of Pharmaceutical Research International. 2020 Nov; 32(28): 74-86. doi: 10.9734/jpri/2020/v32i2830873. DOI: https://doi.org/10.9734/jpri/2020/v32i2830873

De AC Almeida R, Lemos CA, De Moraes SL, Pellizzer EP, Vasconcelos BC. Efficacy of corticosteroids versus placebo in impacted third molar surgery: systematic review and meta-analysis of randomized controlled trials. International Journal of Oral and Maxillofacial Surgery. 2019 Jan; 48(1): 118-31. doi: 10.1016/j.ijom.2018.05.023. DOI: https://doi.org/10.1016/j.ijom.2018.05.023

Tegginamani AS and Prasad R. Histopathologic evaluation of follicular tissues associated with impacted lower third molars. Journal of Oral and Maxillofacial Pathology. 2013 Jan; 17(1): 41-4. doi: 10.4103/0973-029X.110713. DOI: https://doi.org/10.4103/0973-029X.110713

Almadhoon HW, Hamdallah A, Eida MA, Al-Kafarna M, Atallah DA, AbuIriban RW et al. Efficacy of different dexamethasone routes and doses in reducing the postoperative sequelae of impacted mandibular third-molar extraction: a network meta-analysis of randomized clinical trials. The Journal of the American Dental Association. 2022 Dec; 153(12): 1154-70. doi: 10.1016/j.adaj.2022.08.017. DOI: https://doi.org/10.1016/j.adaj.2022.08.017

Graziani F, D’aiuto F, Arduino PG, Tonelli M, Gabriele M. Perioperative dexamethasone reduces post-surgical sequelae of wisdom tooth removal. A split-mouth randomized double-masked clinical trial. International Journal of Oral and Maxillofacial Surgery. 2006 Mar; 35(3): 241-6. doi: 10.1016/j.ijom.2005.07.010. DOI: https://doi.org/10.1016/j.ijom.2005.07.010

Grossi GB, Maiorana C, Garramone RA, Borgonovo A, Beretta M, Farronato D et al. Effect of submucosal injection of dexamethasone on postoperative discomfort after third molar surgery: a prospective study. Journal of Oral and Maxillofacial surgery. 2007 Nov; 65(11): 2218-26. doi: 10.1016/j.joms.2006.11.036. DOI: https://doi.org/10.1016/j.joms.2006.11.036

Poorna P, Shetty P, Kalyani V, Shetty S, Upadya M, Mithra P. A comparative evaluation of the effect of addition of 8 mg dexamethasone to 2% lignocaine with adrenaline in mandibular third molar surgery: a split mouth randomised double blind study. Frontiers in Oral Health. 2024 Feb; 5: 1349832. doi: 10.3389/froh.2024.1349832. DOI: https://doi.org/10.3389/froh.2024.1349832

Djordjević F, Bubalo M, Perić D, Mihailović D, Bukumirić Z, Dubovina D. Effectiveness of submucosal, oral, and intramuscular routes of dexamethasone administration in trismus, swelling, and pain reduction after the third lower molar surgery. Vojnosanitetski pregled. 2023 May; 80(04): 337–342. doi: 10.2298/VSP220331062D. DOI: https://doi.org/10.2298/VSP220331062D

Miroshnychenko A, Azab M, Ibrahim S, Roldan Y, Martinez JP, Tamilselvan D et al. Corticosteroids for managing acute pain subsequent to surgical extraction of mandibular third molars: A systematic review and meta-analysis. The Journal of the American Dental Association. 2023 Aug; 154(8): 727-41. doi: 10.1016/j.adaj.2023.04.018. DOI: https://doi.org/10.1016/j.adaj.2023.04.018

Quesada-Bravo FJ, García-Carricondo AR, Espín-Gálvez F, Fernández-Sánchez C, Fernández-Ginés D, Requena-Mullor MD et al. Comparative study between the combination of dexamethasone and bupivacaine for third molar surgery postoperative pain: a triple-blind, randomized clinical trial. Journal of Clinical Medicine. 2021 Oct; 10(21): 5081. doi: 10.3390/jcm10215081. DOI: https://doi.org/10.3390/jcm10215081

Downloads

Published

2024-08-31
CITATION
DOI: 10.54393/pjhs.v5i08.1982
Published: 2024-08-31

How to Cite

Khalti, I. B., Shaikh, T. H., Kumbhar, A. A., Siddique, S., Zardari, M. H., Bhutto, S.- ul-U., & Channar, K. A. (2024). Effect of Dexamethasone Versus Triamcinolone Acetonide On Postoperative Complications After Impacted Third Molar Surgery: Effect of Dexamethasone vs. Triamcinolone Acetonide on Third Molar Surgery. Pakistan Journal of Health Sciences, 5(08), 98–102. https://doi.org/10.54393/pjhs.v5i08.1982

Issue

Section

Original Article

Plaudit