Comparison of Frequency of Pathogenic Micro-Organisms Causing Bloodstream Infections in Patients Admitted at Tertiary Care Hospital Rawalpindi

Comparison of Pathogens in Bloodstream

Authors

  • Saeed Shafait Department of General Medicine, Pak Emirates Military Hospital, Rawalpindi, Pakistan
  • Shazia Nisar Department of General Medicine, Pak Emirates Military Hospital, Rawalpindi, Pakistan
  • Kinza Nawabi CMP, Pak Emirates Military Hospital, Rawalpindi, Pakistan
  • Hassan Riaz Walsall Healthcare NHS Trust, Walsall, England
  • Ayesha Masood Department of Pathology, College of Medicine and Dentistry, University of Lahore, Pakistan
  • Mehtab Ahmed Naas General Hospital, Co. Kildare, Ireland

DOI:

https://doi.org/10.54393/pjhs.v5i07.1435

Keywords:

Intensive Care Units, Bloodstream, Nosocomial Infections

Abstract

Blood Stream Infections (BSI) are frequently occurring thing in hospital setting and if not tested and appropriate medicine not used, it has significant mortality and also adds an extra burden on health care. Objective: To find the frequency of various pathogenic micro-organisms causing bloodstream infections. Methods: Cross-sectional study was done in tertiary Care Hospital Rawalpindi from April 23 to August 23. Blood samples of 50 patients from two age groups were collected (n=25 above 60 years and n=25 ages 30-60 years). Blood samples were drawn into glass vial containing 20% EDTA to prevent blood clotting and then culture studies were performed. Results: Mean participant age in both study groups was 75.76 ± 8.9 and 46.88 ± 7.7 years (p<0.001). Blood culture analysis revealed that 42 isolates of Staphylococcus aureus was present in >60 years of patients and 55 isolates of Staphylococcus aureus were present in 30-60 years age group.  255 isolates of Escherichia coli. was present in >60 years’ patients and 312 isolates of Escherichia coli were present in 30-60 years’ age group. 9 isolates of Klebsiella was present in >60 years patients and 05 isolates of Klebsiella were present in 30-60 years age group years. Conclusions: Study showed that significant number of microorganism were present in collected blood culture samples. Among various strains of microorganisms, most common is Escherichia coli. Followed by Staphylococcus aureus. Study also highlights that BSI is a frequent occurring problem in hospital setting and if proper antibiotic administered, early cure can be achieved.

References

Viscoli C. Bloodstream infections: the peak of the iceberg. Virulence. 2016 Apr; 7(3): 248-51. doi: 10.1080/21505594.2016.1152440. DOI: https://doi.org/10.1080/21505594.2016.1152440

Vasudeva N, Nirwan PS, Shrivastava P. Bloodstream infections and antimicrobial sensitivity patterns in a tertiary care hospital of India. Therapeutic Advances in Infectious Disease. 2016 Oct; 3(5): 119-27. doi: 10.1177/2049936116666983. DOI: https://doi.org/10.1177/2049936116666983

Laupland KB. Incidence of bloodstream infection: a review of population-based studies. Clinical Microbiology and Infection. 2013 Jun; 19(6): 492-500. doi: 10.1111/1469-0691.12144. DOI: https://doi.org/10.1111/1469-0691.12144

Lochan H, Pillay V, Bamford C, Nuttall J, Eley B. Bloodstream infections at a tertiary level paediatric hospital in South Africa. BMC Infectious Diseases. 2017 Dec; 17: 1-9. doi: 10.1186/s12879-017-2862-2. DOI: https://doi.org/10.1186/s12879-017-2862-2

Nunnally ME, Ferrer R, Martin GS, Martin-Loeches I, Machado FR, De Backer D et al. The Surviving Sepsis Campaign: research priorities for the administration, epidemiology, scoring and identification of sepsis. Intensive Care Medicine Experimental. 2021 Dec; 9: 1-26. doi: 10.1186/s40635-021-00400-z. DOI: https://doi.org/10.1186/s40635-021-00400-z

Droz N, Hsia Y, Ellis S, Dramowski A, Sharland M, Basmaci R et al. Bacterial pathogens and resistance causing community acquired paediatric bloodstream infections in low-and middle-income countries: a systematic review and meta-analysis. Antimicrobial Resistance and Infection Control. 2019 Dec; 8: 1-2. doi: 10.1186/s13756-019-0673-5. DOI: https://doi.org/10.1186/s13756-019-0673-5

Bauer KA, Puzniak LA, Yu KC, Finelli L, Moise P, Ai C et al. Epidemiology and outcomes of culture-positive bloodstream pathogens prior to and during the SARS-CoV-2 pandemic: a multicenter evaluation. BMC Infectious Diseases. 2022 Nov; 22(1): 841. doi: 10.1186/s12879-022-07810-8. DOI: https://doi.org/10.1186/s12879-022-07810-8

Cui J, Li M, Cui J, Wang J, Qiang X, Liang Z et al. The proportion, species distribution and dynamic trends of bloodstream infection cases in a tertiary hospital in China, 2010-2019. Infection. 2022 Feb; 50(1): 121-30. doi: 10.1007/s15010-021-01649-y. DOI: https://doi.org/10.1007/s15010-021-01649-y

Bandy A and Almaeen AH. Pathogenic spectrum of bloodstream infections and resistance pattern in Gram-negative bacteria from Aljouf region of Saudi Arabia. PLOS One. 2020 Jun; 15(6): e0233704. doi: 10.1371/journal.pone.0233704. DOI: https://doi.org/10.1371/journal.pone.0233704

Wang XT, Pan DF, Lu WW, Chen C, Su M, Meng H et al. Multidrug-resistant bacteria may be associated with bed allocation and utilization efficiency in healthcare institutions, based on national monitoring data from China. 2023 Dec. doi: 10.21203/rs.3.rs-2738569/v1. DOI: https://doi.org/10.21203/rs.3.rs-2738569/v1

Serra-Burriel M, Keys M, Campillo-Artero C, Agodi A, Barchitta M, Gikas A et al. Impact of multi-drug resistant bacteria on economic and clinical outcomes of healthcare-associated infections in adults: Systematic review and meta-analysis. PloS One. 2020 Jan; 15(1): e0227139. doi: 10.1371/journal.pone.0227139. DOI: https://doi.org/10.1371/journal.pone.0227139

Nathwani D, Varghese D, Stephens J, Ansari W, Martin S, Charbonneau C et al. Value of hospital antimicrobial stewardship programs [ASPs]: a systematic review. Antimicrobial Resistance & Infection Control. 2019 Dec; 8: 1-3. doi: 10.1186/s13756-019-0471-0. DOI: https://doi.org/10.1186/s13756-019-0471-0

Schinas G, Polyzou E, Spernovasilis N, Gogos C, Dimopoulos G, Akinosoglou K et al. Preventing multidrug-resistant bacterial transmission in the intensive care unit with a comprehensive approach: a policymaking manual. Antibiotics. 2023 Jul; 12(8): 1255. doi: 10.3390/antibiotics12081255. DOI: https://doi.org/10.3390/antibiotics12081255

Huo X. Modeling Antibiotic Use Strategies in Intensive Care Units: Comparing De-escalation and Continuation. Bulletin of Mathematical Biology. 2020 Jan; 82: 1-31. doi: 10.1007/s11538-019-00686-x. DOI: https://doi.org/10.1007/s11538-019-00686-x

Chatzopoulou M and Reynolds L. Systematic review of the effects of antimicrobial cycling on bacterial resistance rates within hospital settings. British Journal of Clinical Pharmacology. 2022 Mar; 88(3): 897-910. doi: 10.1111/bcp.15042. DOI: https://doi.org/10.1111/bcp.15042

Haseeb A, Faidah HS, Al-Gethamy M, Iqbal MS, Barnawi AM, Elahe SS et al. Evaluation of a multidisciplinary antimicrobial stewardship program in a Saudi critical care unit: A quasi-experimental study. Frontiers in Pharmacology. 2021 Mar; 11: 570238. doi: 10.3389/fphar.2020.570238. DOI: https://doi.org/10.3389/fphar.2020.570238

Huang Q, Horn MA, Ruan S. Modeling the effect of antibiotic exposure on the transmission of methicillin-resistant Staphylococcus aureus in hospitals with environmental contamination. Mathematical Biosciences and Engineering. 2019 Apr; 16(5): 3641-73. doi: 10.3934/mbe.2019181. DOI: https://doi.org/10.3934/mbe.2019181

Ticona JH, Zaccone VM, McFarlane IM. Community-acquired pneumoniae: A focused review. American Journal of Medical Case Reports. 2021 Nov; 9(1): 45-52. doi: 10.12691/ajmcr-9-1-12. DOI: https://doi.org/10.12691/ajmcr-9-1-12

Choi H, Ahn H, Lee R, Cho SY, Lee DG. Bloodstream infections in patients with hematologic diseases: Causative organisms and factors associated with resistance. Infection and Chemotherapy. 2022 Jun; 54(2): 340. doi: 10.3947/ic.2022.0069. DOI: https://doi.org/10.3947/ic.2022.0069

Santoro A, Franceschini E, Meschiari M, Menozzi M, Zona S, Venturelli C et al. Epidemiology and risk factors associated with mortality in consecutive patients with bacterial bloodstream infection: impact of MDR and XDR bacteria. Open Forum Infectious Diseases. 2020 Nov; 7(11): 461. doi: 10.1093/ofid/ofaa461. DOI: https://doi.org/10.1093/ofid/ofaa461

González-Alsina A, Mateu-Borrás M, Doménech-Sánchez A, Albertí S. Pseudomonas aeruginosa and the complement system: a review of the evasion strategies. Microorganisms. 2023 Mar; 11(3): 664. doi: 10.3390/microorganisms11030664. DOI: https://doi.org/10.3390/microorganisms11030664

Downloads

Published

2024-07-31
CITATION
DOI: 10.54393/pjhs.v5i07.1435
Published: 2024-07-31

How to Cite

Shafait, S., Nisar, S., Nawabi, K., Riaz, H., Masood, A., & Ahmed, M. (2024). Comparison of Frequency of Pathogenic Micro-Organisms Causing Bloodstream Infections in Patients Admitted at Tertiary Care Hospital Rawalpindi: Comparison of Pathogens in Bloodstream. Pakistan Journal of Health Sciences, 5(07), 115–119. https://doi.org/10.54393/pjhs.v5i07.1435

Issue

Section

Original Article

Plaudit